Eukaryotic mRNA 3' processing: a common means to different ends

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Eukaryotic mRNA 3' processing: a common means to different ends.

In principle, the formation of the 3 end of a eukaryotic mRNA is a simple process. At a minimum, it involves the hydrolysis of a single phosphodiester bond in the nascent transcript. For one unique class of mRNAs, transcripts of the metazoan replication-dependent histone genes, this is indeed the only requirement. All other eukaryotic mRNAs require both cleavage and subsequent poly(A) addition ...

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ژورنال

عنوان ژورنال: Genes & Development

سال: 2005

ISSN: 0890-9369

DOI: 10.1101/gad.1378105